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Mouse Mesothelin (298-600), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Mouse Mesothelin (298-600), His Tag at 2 ug/mL (100 uL/well) can bind Biotinylated Human CA125, Fc,Avitag with a linear range of 0.6-10 ng/mL (QC tested).
Mouse Mesothelin (298-600), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Mesothelin / MSLN (298-600) Recombinant Protein

CATALOG NUMBER: 11-217

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Mouse
source-species:
HEK293 cells
Recombinant Protein Sequence:
Asp 298 - Ser 600
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.0 kDa. The protein migrates as 42-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
36.0 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
Msln
Additional Names:
MSLN,Mesothelin,MPF
Protein Accession Number:
NP_061345.1
Ncbi Gene Id Number:
56047
Background:
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
Background Reference 1:
Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140.
Background Reference 2:
Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808.
Background Reference 3:
Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198.
Background Reference 4:
Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-217

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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