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Western blot analysis in K562 cell line lysates (35ug/lane).
Western blot analysis of METAP2 using rabbit polyclonal METAP2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the METAP2 gene.
Western blot analysis in K562 cell line lysates (35ug/lane).

METAP2 Antibody

CATALOG NUMBER: 57-699

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This METAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human METAP2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
53 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
METAP2
Additional Names:
Methionine aminopeptidase 2 {ECO:0000255, HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255, HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255, HAMAP-Rule:MF_03175}, 341118 {ECO:0000255, HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255, HAMAP-Rule:MF_03175}, p67 {ECO:0000255, HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255, HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255, HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255, HAMAP-Rule:MF_03175}
Protein Accession Number:
P50579
Protein Gi Number:
1703273
Ncbi Gene Id Number:
10988
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene is a member of the methionyl aminopeptidasefamily and encodes a protein that binds 2 cobalt or manganese ions.This protein functions both by protecting the alpha subunit ofeukaryotic initiation factor 2 from inhibitory phosphorylation andby removing the amino-terminal methionine residue from nascentprotein. Increased expression of this gene is associated withvarious forms of cancer and the anti-cancer drugs fumagillin andovalicin inhibit the protein by irreversibly binding to its activesite. A pseudogene of this gene is located on chromosome 2.
Background Reference 1:
Xiao, Q., et al. Biochemistry 49(26):5588-5599(2010)
Background Reference 2:
Wang, X., et al. PLoS ONE(8), E11934 (2010) :
Background Reference 3:
Selvakumar, P., et al. Mol. Cancer 8, 65 (2009) :
Background Reference 4:
Warder, S.E., et al. J. Proteome Res. 7(11):4807-4820(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-699

List Size:
400 ul

List Price:

$495.00

Datasheet
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