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MIA Recombinant Protein

CATALOG NUMBER: 40-226

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
MGPMPKLADR KLCADQECSH PISMAVALQD YMAPDCRFLT IHRGQVVYVF SKLKGRGRLF WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKPGKVDVKT DKWDFYCQ
Biological Activity:
The ED50 was determined by the dose - dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4 - 6 μg/mL.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized MIA recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted MIA is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing MIA recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
MIA
Additional Names:
CD-RAP, Melanoma-derived growth regulatory protein, Melanoma inhibitory activity protein
Protein Accession Number:
NP_001189482.1
Protein Gi Number:
321400133
Ncbi Gene Id Number:
8190
Background:
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-226

List Size:
0.005 mg, 0.02 mg

List Price:

Price range: $215.00 through $323.00

Datasheet
Shipping Info

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