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MLK1/2 (phospho Thr312/266) Antibody

CATALOG NUMBER: 79-857

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
MLK1/2 (phospho Thr312/266) antibody was raised against a peptide sequence around phosphorylation site of threonine 312/266 (A-G-T (p)-Y-A) derived from Human MLK1/2.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of MLK1/2 only when phosphorylated at threonine 312/266.
Predicted Molecular Weight:
121 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20˚,C for up to one year.
Ncbi Official Symbol:
MAP3K9, MAP3K10
Additional Names:
M3K9, PRKE1, mixed-lineage protein kinase 1
Protein Accession Number:
NP_001271159.1
Protein Gi Number:
52421790
Ncbi Gene Id Number:
4293;4294
Background:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Background Reference 1:
Durkin J.T., Biochemistry 43:16348-16355(2004).
Background Reference 2:
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Background Reference 3:
Dorow D.S.,Nature 446:153-158(2007).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-857

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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