MMP2 Antibody

Background:

Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This gene encodes an enzyme whichdegrades type IV collagen, the major structural component ofbasement membranes. The enzyme plays a role in endometrialmenstrual breakdown, regulation of vascularization and theinflammatory response. Mutations in this gene have been associatedwith Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO)syndrome. Two transcript variants encoding different isoforms havebeen found for this gene.