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Recombinant Mouse ALK-4/ACVR1B Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Immobilized Mouse TDGF1 (Catalog: 85-922) at 5 μg/mL (100 μL/well) can bind Mouse ALK4(Catalog: 85-803) with a linear range of 4.5-133.2 ng/mL.
Recombinant Mouse ALK-4/ACVR1B Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Mouse ALK-4/ACVR1B Recombinant Protein (85-803)

CATALOG NUMBER: 85-803

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Mouse
source-species:
HEK293 cells
Recombinant Protein Sequence:
Met1-Glu126
Fusion Tag:
C-hFc
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
37.30 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Mouse TDGF1 at 5 μg/mL (100 μL/well) can bind Mouse ALK4 with a linear range of 4.5-133.2 ng/mL.
Purity:
≥ 90 % as determined by SDS-PAGE.
Endotoxin:
< 0.01 EU/μg of the protein by LAL method
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
Alk4; SKR2; ALK-4; ActRIB; ActR-IB; Acvrlk4; 6820432J04
Protein Accession Number:
NP_031421.1
Ncbi Gene Id Number:
11479
Background:
ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-803

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $112.00 through $280.00

Datasheet
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