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Western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstratedetected the Src protein (arrow).
Western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstratedetected the Src protein (arrow).

Mouse Src Antibody

CATALOG NUMBER: 59-107

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Immunogen:
This Mouse Src antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-125 amino acids from the N-terminal region of mouse Src.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
61 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
Src
Additional Names:
Neuronal proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src, p60-Src, Src
Protein Accession Number:
P05480
Ncbi Gene Id Number:
20779
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.
Background Reference 1:
Tanji, M., et al. Mol. Cell. Biol. 30(19):4604-4615(2010)
Background Reference 2:
Wang, L., et al. J. Neurosci. 30(39):13201-13210(2010)
Background Reference 3:
Tu, C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16107-16112(2010)
Background Reference 4:
Zheng, Y., et al. Mol. Cell. Biol. 30(17):4280-4292(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-107

List Size:
400 ul

List Price:

$495.00

Datasheet
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