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Western blot analysis in mouse stomach tissue lysates (35ug/lane).
Western blot analysis in mouse stomach tissue lysates (35ug/lane).

Mouse Txnip Antibody

CATALOG NUMBER: 60-886

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
44 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
Txnip
Additional Names:
Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1
Protein Accession Number:
Q8BG60
Ncbi Gene Id Number:
56338
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
Background Reference 1:
Kwon, H.J., et al. Toxicol. Appl. Pharmacol. 248(3):277-284(2010)
Background Reference 2:
Kwon, H.J., et al. J. Immunol. 185(7):3980-3989(2010)
Background Reference 3:
Ren, Y., et al. FEBS Lett. 584(15):3480-3485(2010)
Background Reference 4:
Chutkow, W.A., et al. Diabetes 59(6):1424-1434(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-886

List Size:
400 ul

List Price:

$495.00

Datasheet
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