MPZL2 Antibody

Background:

Thymus development depends on a complex series ofinteractions between thymocytes and the stromal component of theorgan. Epithelial V-like antigen (EVA) is expressed in thymusepithelium and strongly downregulated by thymocyte developmentalprogression. This gene is expressed in the thymus and in severalepithelial structures early in embryogenesis. It is highlyhomologous to the myelin protein zero and, in thymus-derivedepithelial cell lines, is poorly soluble in nonionic detergents,strongly suggesting an association to the cytoskeleton. Itscapacity to mediate cell adhesion through a homophilic interactionand its selective regulation by T cell maturation might imply theparticipation of EVA in the earliest phases of thymusorganogenesis. The protein bears a characteristic V-type domain andtwo potential N-glycosylation sites in the extracellular domain; aputative serine phosphorylation site for casein kinase 2 is alsopresent in the cytoplasmic tail. Two transcript variants encodingthe same protein have been found for this gene. [provided byRefSeq].