MRPS12 Antibody

Background:

Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. This gene encodes a 28S subunit protein that belongs tothe ribosomal protein S12P family. The encoded protein is a keycomponent of the ribosomal small subunit and controls the decodingfidelity and susceptibility to aminoglycoside antibiotics. The genefor mitochondrial seryl-tRNA synthetase is located upstream andadjacent to this gene, and both genes are possible candidates forthe autosomal dominant deafness gene (DFNA4). Splice variants thatdiffer in the 5' UTR have been found for this gene; all threevariants encode the same protein.