MRPS15 Antibody

Background:

Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. This gene encodes a 28S subunit protein that belongs tothe ribosomal protein S15P family. The encoded protein is more thantwo times the size of its E. coli counterpart, with the 12S rRNAbinding sites conserved. Between human and mouse, the encodedprotein is the least conserved among small subunit ribosomalproteins. Pseudogenes corresponding to this gene are found onchromosomes 15q and 19q.