MRPS31 Antibody

Background:

Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. The 28S subunit of the mammalian mitoribosome may play acrucial and characteristic role in translation initiation. Thisgene encodes a 28S subunit protein that has also been associatedwith type 1 diabetes; however, its relationship to the etiology ofthis disease remains to be clarified. Pseudogenes corresponding tothis gene have been found on chromosomes 3 and 13. [provided byRefSeq].