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Western blot analysis of MS4A6A in 293 cell lysate with MS4A6A antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of MS4A6A in rat brain tissue with MS4A6A antibody at 2.5 μg/mL.
Immunofluorescence of MS4A6A in rat brain tissue with MS4A6A antibody at 20 μg/mL.
Western blot analysis of MS4A6A in 293 cell lysate with MS4A6A antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

MS4A6A Antibody

CATALOG NUMBER: 6593

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Rat
Immunogen:
MS4A6A antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human MS4A6A.
The immunogen is located within the first 50 amino acids of MS4A6A.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
MS4A6A antibody can be used for detection of MS4A6A by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Specificity:
At least three isoforms of MS4A6A are known to exist; this antibody will detect the two longer isoforms. MS4A6A antibody is predicted to not cross-react with MS4A family members.
Positive Control 1:
Cat. No. 1210 - HEK293 Cell Lysate
Purification:
MS4A6A Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
MS4A6A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
MS4A6A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MS4A6A
Additional Names:
MS4A6A Antibody: CDA01, MS4A6, 4SPAN3, CD20L3, MST090, MSTP090, 4SPAN3.2, CDA01, Membrane-spanning 4-domains subfamily A member 6A, CD20 antigen-like 3
Protein Accession Number:
NP_071744
Protein Gi Number:
23238238
Ncbi Gene Id Number:
64231
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
MS4A6A Antibody: The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other genes encoding membrane proteins, most having characteristic tetraspanning topology and similar intron/exon splice boundaries. All family members display unique expression patterns among hematopoietic cells and non-lymphoid tissues. The function of MS4A6A has been suggested to be involved in signal transduction as a component of a multimeric receptor complex in Alzheimer's disease and cancer.
Background Reference 1:
Liang Y and Tedder TF. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics 2001; 72:119-27
Background Reference 2:
Ishibashi K, Suzuki M, Sasaki S, et al. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene 2001; 264:87-93.
Background Reference 3:
Antúnez C, Boada M, Gonzalez-Pérez A, et al. The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. Genome Med. 2011; 3:33
Background Reference 4:
Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 2011; 43:429-35.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6593

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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