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Western Blot at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: HL-60 whole cell lysate Lysates/proteins at 20 ug per lane.
Western blot showing knockdown of endogenous MTM1 expression by MTM1-targeting vectors pDM134 and pDM170. Embryonic stem (ES) cells were untreated (lane 1) or transfected with control plasmid pDCont (lane 2), MTM1-targeting plasmid pDM134 (lane 3), or pDM170 (lane 4). The blot was probed with anti-MTM1 rabbit polyclonal antibodies. -Actin was used as a loading control.
Western Blot at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: HL-60 whole cell lysate Lysates/proteins at 20 ug per lane.

MTM1 Antibody

CATALOG NUMBER: 62-480

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
70 kDa
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MTM1
Additional Names:
Myotubularin, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, MTM1, CG2
Protein Accession Number:
Q13496
Protein Gi Number:
2851537
Ncbi Gene Id Number:
4534
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.
Background Reference 1:
Nandurkar, H.H., et al., Proc. Natl. Acad. Sci. U.S.A. 100(15):8660-8665 (2003).
Background Reference 2:
Biancalana, V., et al., Hum. Genet. 112(2):135-142 (2003).
Background Reference 3:
Wishart, M.J., et al., Trends Cell Biol. 12(12):579-585 (2002).
Background Reference 4:
Herman, G.E., et al., Hum. Mutat. 19(2):114-121 (2002).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

62-480

List Size:
400 ul

List Price:

$495.00

Datasheet
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