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Human Mucin-1 (1036-1155), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Human Mucin-1 (1036-1155), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Mucin-1 / MUC-1 (1036-1155) Recombinant Protein

CATALOG NUMBER: 11-281

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Leu 1036 - Gly 1155
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 7.2 kD
Predicted Molecular Weight:
7.2 kDa (partial α chain) & 8.2 kDa (partial β chain)
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Names:
Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin
Background:
Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
Background Reference 1:
Gendler SJ., et al., 1990, J. Biol. Chem. 265 (25): 15286-93.
Background Reference 2:
Hollingsworth MA., et al., 2004, Nat. Rev. Cancer 4 (1): 45-60.
Background Reference 3:
Moncada DM., et al., 2003, Trends Parasitol 19 (7): 305-311.
Background Reference 4:
Singh PK., et al., 2006, Trends Cell Biol 16 (9): 467-476.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-281

List Size:
0.1 mg

List Price:

$577.00

Datasheet
Shipping Info

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