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Immunohistochemistry of MYBPC1 in human skeletal muscle tissue with MYBPC1 antibody at 5 μg/mL.
Immunohistochemistry of MYBPC1 in human skeletal muscle tissue with MYBPC1 antibody at 5 μg/mL.
Trial Size

MYBPC1 Antibody

CATALOG NUMBER: 5649

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
MYBPC1 antibody was raised against a 12 amino acid synthetic peptide near the carboxy terminus of human MYBPC1.
The immunogen is located within the last 50 amino acids of MYBPC1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P
Application Note:
MYBPC1 antibody can be used for detection of MYBPC1 by immunohistochemistry at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate
Purification:
MYBPC1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
MYBPC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
MYBPC1 antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MYBPC1
Additional Names:
MYBPC1 Antibody: LCCS4, MYBPCC, MYBPCS, Myosin-binding protein C, slow-type, C-protein, skeletal muscle slow isoform, Slow MyBP-C
Protein Accession Number:
NP_002456
Protein Gi Number:
45976288
Ncbi Gene Id Number:
4604
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
MYBPC1 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the slow-type isoform designated MYBPC1. Both the fast-type (MYBPC2) and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. Multiple isoforms of MYBPC1 are known to exist, and are present in varying amounts in different skeletal muscles. It is thought that the MYBPC1 slow subfamily may play important roles in the assembly and stabilization of sarcomeric M- and A-bands and regulate the contractile properties of the actomyosin filaments.
Background Reference 1:
Furst DO, Vinkemeir U and Weber K. Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA. J. Cell Sci. 1992; 102:769-78.
Background Reference 2:
Weber FE, Vaughan KT, Reiach FC, et al. Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. Eur. J. Biochem. 1993; 216:661-9.
Background Reference 3:
Ackermann MA and Kontrogianni-Konstantopoulous A. Myosin binding protein-C slow: an intricate subfamily of proteins. J. Biomed. Biotech. 2010; 2010:652065

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5649

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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