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Antibody staining MYBPC3 in human skeletal muscle tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
Antibody staining MYBPC3 in human heart tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
Antibody staining MYBPC3 in human heart tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
Western Blot at 1:2000 dilution Lane 1: mouse heart lysate Lane 2: rat heart lysate Lysates/proteins at 20 ug per lane.
Western Blot at 1:1000-1:2000 dilution Lane 1: human liver lysate Lane 2: mouse heart lysate Lane 3: rat heart lysate Lysates/proteins at 20 ug per lane.
Western blot analysis of lysate from rat heart tissue lysate, using MYBPC3 Antibody at 1:1000.
Western blot analysis of lysate from mouse heart tissue lysate, using MYBPC3 Antibody at 1:1000.
Antibody staining MYBPC3 in human skeletal muscle tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).

MYBPC3 Antibody

CATALOG NUMBER: 56-426

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
This MYBPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
141 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit IgG
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MYBPC3
Additional Names:
Myosin-binding protein C, cardiac-type, Cardiac MyBP-C, C-protein, cardiac muscle isoform, MYBPC3
Protein Accession Number:
Q14896
Protein Gi Number:
425906074
Ncbi Gene Id Number:
4607
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
MYBPC3 encodes the cardiac isoform of myosin-bindingprotein C. Myosin-binding protein C is a myosin-associated proteinfound in the cross-bridge-bearing zone (C region) of A bands instriated muscle. MYBPC3, the cardiac isoform, is expressedexclussively in heart muscle. Regulatory phosphorylation of thecardiac isoform in vivo by cAMP-dependent protein kinase (PKA) uponadrenergic stimulation may be linked to modulation of cardiaccontraction. Mutations in MYBPC3 are one cause of familialhypertrophic cardiomyopathy.
Background Reference 1:
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Background Reference 2:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 3:
Millat, G., et al. EurMed Genet 53(5):261-267(2010)
Background Reference 4:
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-426

List Size:
400 ul

List Price:

$495.00

Datasheet
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