MYOM1 Antibody

Background:

The giant protein titin, together with its associatedproteins, interconnects the major structure of sarcomeres, the Mbands and Z discs. The C-terminal end of the titin string extendsinto the M line, where it binds tightly to M-band constituents ofapparent molecular masses of 190 kD (myomesin 1) and 165 kD(myomesin 2). This protein, myomesin 1, like myomesin 2, titin, andother myofibrillar proteins contains structural modules with stronghomology to either fibronectin type III (motif I) or immunoglobulinC2 (motif II) domains. Myomesin 1 and myomesin 2 each have a uniqueN-terminal region followed by 12 modules of motif I or motif II, inthe arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteinsshare 50% sequence identity in this repeat-containing region. Thehead structure formed by these 2 proteins on one end of the titinstring extends into the center of the M band. The integratingstructure of the sarcomere arises from muscle-specific members ofthe superfamily of immunoglobulin-like proteins. Alternativelyspliced transcript variants encoding different isoforms have beenidentified.