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NAIP1/2/5 Antibody [Naipa-1]

CATALOG NUMBER: 36-158

Clonality:
Monoclonal
Tested Applications:
WB
Host Species:
Mouse
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Mouse
Immunogen:
Recombinant mouse NAIP5 (BIR2 domain/aa 159-227).
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: (1ug/ml).
Specificity:
Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain.
Purification:
>95% (SDS-PAGE)
Clonality:
Monoclonal
Isotype:
IgG2b, kappa
physical-state:
Liquid
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Storage Conditions:
Stable for at least 1 year after receipt when stored at -20°C.
Ncbi Official Symbol:
Naip5
Additional Names:
Neuronal Apoptosis Inhibitory Protein 1, 2, 5; Baculoviral IAP Repeat-containing Protein 1a, 1b, 1e; Birc 1a, 1b, 1e
Protein Accession Number:
12643317
Protein Gi Number:
Q9R016
Ncbi Gene Id Number:
17951
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

36-158

List Size:
100 ug

List Price:

$577.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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