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Western blot of rat cortex lysate showing specific immunolableing of the ~ 68k NF-L protein.
Western blot of rat cortex lysate showing specific immunolableing of the ~ 68k NF-L protein.

Neurofilament NF-L Antibody

CATALOG NUMBER: 50-256

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Chicken
Species Reactivity:
Bovine, Chicken, Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Chicken
Species Reactivity:
Bovine, Chicken, Human, Mouse, Rat
Immunogen:
Preparation of bovine spinal cord intermediate filaments
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Specificity:
Specific for the ~68k Neurofilament L protein in Western blots and works well on frozen sections, cells in tissue culture and on mildly formalin fixed histological sections.
Predicted Molecular Weight:
68
Purification:
Total IgY fraction
Clonality:
Polyclonal
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
Neurofilament NF-L antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
NEFL
Protein Accession Number:
P07196
Protein Gi Number:
62511894
Ncbi Gene Id Number:
4747
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68 kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease.
Background Reference 1:
Harris, J., Ayyub, C. and Shaw G. (1991) A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J Neurosci Res 30:47-62.
Background Reference 2:
Mersiyanova IV, Perepelov AV, Polyakov AV, Sitnikov VF, Dadali EL, Oparin RB, PetrinAN and Evgrafov OV. (2000) A new variant of Charcot-Marie-Tooth disease type 2 isprobably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet.67:37-46.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-256

List Size:
0.1 mL

List Price:

$495.00

Datasheet
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