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Western blot analysis of (A) 25 ng, (B) 50 ng, and (C) 100 ng of purified recombinant NGFR with NGFR antibody at 1 μg/mL.
Immunocytochemistry of NGFR in A20 cells with NGFR antibody at 10 μg/mL.
Immunofluorescence of NGFR in HepG2 cells with NGFR antibody at 20 μg/mL.<br><br>Green: NGFR Antibody (3593) <br> Blue: DAPI staining
Western blot analysis of (A) 25 ng, (B) 50 ng, and (C) 100 ng of purified recombinant NGFR with NGFR antibody at 1 μg/mL.
Green Product
Trial Size

NGFR Antibody

CATALOG NUMBER: 3593

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
NGFR antibody was raised against purified recombinant human NGFR.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, IF, WB
Application Note:
NGFR antibody can be used for the detection of NGFR by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in mouse samples and Immunofluorescence in human samples. . All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1288 - A20 Cell Lysate
Positive Control 2:
Cat. No. 17-208 - A-20 Cell Slide
Purification:
NGFR Antibody is Protein A purified.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
NGFR Antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
NGFR antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
NGFR
Additional Names:
NGFR Antibody: CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, Tumor necrosis factor receptor superfamily member 16, NGF receptor
Protein Accession Number:
NP_002498
Protein Gi Number:
4505393
Ncbi Gene Id Number:
4804
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
NGFR Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family. Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination. Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4. NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins. Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR.
Background Reference 1:
Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol. 2003; 66:1403-8.
Background Reference 2:
Johnson D, Lanahon A, Buck CR, et al. Expression and structure of the human NGF receptor. Cell 1986; 47:545-54.
Background Reference 3:
Gentry JJ, Barker, PA, and Carter BD. The p75 neuro-trophin receptor: multiple interactors and numerous functions. Prog. Brain Res. 2004;146:25-39.
Background Reference 4:
Nykjaer A, Willnow TE, and Petersen CM. p75NTR - live or let die. Curr. Opin. Neurobio. 2005; 15:49-57.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3593

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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