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Western blot analysis of NGN2 in mouse small intestine tissue lysate with NGN2 antibody at (A) 1 and (B) 2 μg/mL.
Immunofluorescence of NGN2 in human brain tissue with NGN2 antibody at 20 μg/mL.
Western blot analysis of NGN2 in mouse small intestine tissue lysate with NGN2 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

NGN2 Antibody

CATALOG NUMBER: 7091

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Rabbit polyclonal NGN2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human NGN2.
The immunogen is located within the last 50 amino acids of NGN2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
NGN2 antibody can be used for detection of NGN2 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
NGN2 antibody is predicted to not cross-react with neurogenin 1.
Positive Control 1:
Cat. No. 1408 - Mouse Small Intestine Tissue Lysate
Positive Control 2:
Cat. No. 10-301 - Human Brain Tissue Slide
Predicted Molecular Weight:
30 kDa
Purification:
NGN2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
NGN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
NGN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
NEUROG2
Additional Names:
NGN2 Antibody: NGN2, Atoh4, ngn-2, Math4A, bHLHa8, ATOH4, BHLHA8, NGN2, Neurogenin-2, Class A basic helix-loop-helix protein 8, NGN-2
Protein Accession Number:
NP_076924
Protein Gi Number:
31077092
Ncbi Gene Id Number:
63973
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
NGN2 Antibody: Neurogenin-2 (NGN2) is a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. NGN2 is thought to work with Nurr1 to play a role in the differentiation and survival of midbrain dopaminergic neurons. It has also been suggested for use in human embryonic neural progenitors as a graft for spinal cord injuries
Background Reference 1:
Sommer L, Ma Q, and Anderson DJ. Neurogenins, a novel family of atonal-related bHLH transcription factors, a putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell Neurosci. 1996; 8:221-41.
Background Reference 2:
Fode C, Gradwohl G, Morin X, et al. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 1998; 20:483-94.
Background Reference 3:
Andersson EK, Irvin DK, Ahlsio J, et al. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Exp. Cell. Res. 2007; 313:1172-80.
Background Reference 4:
Perrin FE, Boniface G, Serguera C, et al. Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. PLoS One 2010; 5:e15914.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7091

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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