Start Your Project

🛍️Explore our Promotions page to discover current deals, limited-time offers, and more!🌟

NMDA NR1 Subunit Antibody
NMDA NR1 Subunit Antibody

NMDA NR1 Antibody [R1JHL]

CATALOG NUMBER: XPS-2019

Clonality:
Monoclonal
Tested Applications:
IP, WB
Host Species:
Mouse
Species Reactivity:
Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Rat
Immunogen:
NMDA NR1 Subunit monoclonal antibody was raised against a fusion protein from AA 1 - 564 of NMDA NR1.
Conjugate:
Unconjugated
Tested Applications:
IP, WB
Application Note:
NMDA NR1 Subunit antibody allows for strong and specific immunolabeling of the 120k NR1 protein in Western blots of rat brain hippocampal homogenate. Applications include Dot Blots (DB), Immunoprecipitation (IP) and Western Blots (WB). Mouse anti-NMDA NR1 Subunit recognizes NR1 in human, mouse and rat brain lysates. When internally tested under ideal conditions the working dilutions were 1:300 for DB and WB, and 3 μg per 200 μg lysate (will quantitatively precipitate all the NMDA NR1 in 200 μg of rat brain lysate).
Predicted Molecular Weight:
120
Purification:
Affinity Purified
Clonality:
Monoclonal
physical-state:
Lyophilized
Concentration:
batch dependent
Storage Conditions:
NMDA NR1 Subunit antibody can be stored at -20°C. After reconstitution in 50 μl water, the antibody should be aliquot and stored at -20°C. This product is stable at -20°C for at least 1 year and can be shipped ambient domestic or international.
Ncbi Official Symbol:
Grin1
Protein Accession Number:
P35439
Protein Gi Number:
548379
Ncbi Gene Id Number:
24408
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity.
Background Reference 1:
Luo, J.H., Wang, Y.H., Yasuda, R.P., Dunah, A.W. and Wolfe, B.B., "The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B)," Mol. Pharmacol. 51 (1997) 79 - 86.
Background Reference 2:
Grosshans, D.R., Clayton, D.A., Coultrap, S.J., and Browning, M.D., "LTP leads to rapid surface expression on NMDA not AMPA receptors in adult rat CA1," Nature Neurosci., 5 (2002) 27 - 33.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

XPS-2019

List Size:
15 ug

List Price:

$540.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

Customize your order

Bulk Pricing Available

Custom Formulations: azide free, endotoxin testing & endotoxin removal.

Pair your antibody with a Lysate, Peptide, Control, & /OR Secondary Antibody.

Contact our Customer Care Team for more information

Custom Antibody Services

Speak to one of our custom antibody specialists to discuss your next custom antibody project.

New & Featured Products

HIV-1 p24 Antibody [9D2F6] (HRP)
HIV-1 p24 Antibody [9D2F6] (HRP)

CATALOG NUMBER: PM-7369-HRP

HIV-1 p24 Antibody [9D2F6] (biotin)
HIV-1 p24 Antibody [9D2F6] (biotin)

CATALOG NUMBER: PM-7369-biotin

HIV-1 p24 Antibody [9D2F6]
HIV-1 p24 Antibody [9D2F6]

CATALOG NUMBER: PM-7369