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Human NOTCH2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human DLL4, His Tag at 5 ug/mL (100 uL/well) can bind Human NOTCH2, Fc Tag with a linear range of 5-78 ng/mL (QC tested).
Immobilized Human NOTCH2, Fc Tag at 1 ug/mL (100 uL/well) can bind Bispecific Antibody (NOTCH2 × NOTCH3) with a linear range of 1-20 ng/mL (Routinely tested).
Human NOTCH2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

NOTCH2 Recombinant Protein

CATALOG NUMBER: 11-164

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Leu 26 - Gln 530
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 80.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
80.5 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
NOTCH2
Additional Names:
NOTCH2,hN2,N2ECD
Protein Accession Number:
NP_077719.2
Ncbi Gene Id Number:
4853
Background:
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .
Background Reference 1:
Michael A Simpson, et. al., 2011, Nat Genet.6;43(4):303-5.
Background Reference 2:
Isidor B, et. al., 2011, Nat. Genet. 43:306-308.
Background Reference 3:
Fukushima H, et. al., 2017, Mol. Cell. 68:645-658.
Background Reference 4:
Zhu PNat, et. al., 2015, Commun. 6:7122-7122.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-164

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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