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Antibody used in IHC on Human Breast at 5.0 ug/ml.
Antibody used in WB on Human Jurkat 0.2-1 ug/ml.
Antibody used in IHC on Human Breast at 5.0 ug/ml.

NOTCH4 Antibody

CATALOG NUMBER: 27-681

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NOTCH4.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
NOTCH4 antibody can be used for detection of NOTCH4 by ELISA at 1:312500. NOTCH4 antibody can be used for detection of NOTCH4 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Positive Control 1:
Cat. No. 1205 - Jurkat Cell Lysate
Predicted Molecular Weight:
65 kDa, 210 kDa
Purification:
Antibody is purified by peptide affinity chromatography method.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Storage Conditions:
For short periods of storage (days) store at 4°C. For longer periods of storage, store NOTCH4 antibody at -20°C. As with any antibody avoid repeat freeze-thaw cycles.
Ncbi Official Symbol:
NOTCH4
Additional Names:
NOTCH4, INT3, NOTCH3
Protein Accession Number:
Q99466-2
Protein Gi Number:
20139103
Ncbi Gene Id Number:
4855
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. NOTCH4 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH4 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. NOTCH4 gene may be associated with susceptibility to schizophrenia in a small portion of cases.
Background Reference 1:
Sugaya K., et al., (1997) Gene 189:235-244.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

27-681

List Size:
100 ul

List Price:

$519.00

Datasheet
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