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NP-1 Recombinant Protein

CATALOG NUMBER: 40-130

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
ACYCRIPACI AGERRYGYCI YQGRLWAFCC
Biological Activity:
Determined by its ability to induce adhesion of HUVECs. The expected ED₅₀ so for this effect is 1.5- 2.5 μg/ml.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized NP-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted NP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing NP-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
DEFA1
Additional Names:
HP1, MRS, DEF1, HP-1, DEFA2, HNP-1, DEFA1B, Neutrophil defensin 1, Defensin, alpha 1
Protein Accession Number:
NP_004075.1
Protein Gi Number:
4758146
Ncbi Gene Id Number:
1667
Background:
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-130

List Size:
0.005 mg, 0.02 mg

List Price:

Price range: $215.00 through $323.00

Datasheet
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