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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis in 293 cell line lysates (35ug/lane).

NPC1L1 Antibody

CATALOG NUMBER: 60-959

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This NPC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the N-terminal region of human NPC1L1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
149 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
NPC1L1
Additional Names:
Niemann-Pick C1-like protein 1, NPC1L1
Protein Accession Number:
Q9UHC9
Protein Gi Number:
425906049
Ncbi Gene Id Number:
29881
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is a multi-pass membraneprotein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1)domain and a putative sterol-sensing domain (SSD) which includes aYQRL motif functioning as a plasma membrane to trans-Golgi networktransport signal in other proteins. This protein takes up freecholesterol into cells through vesicular endocytosis and plays acritical role in the absorption of intestinal cholesterol. It alsohas the ability to transport alpha-tocopherol (vitamin E). The drugezetimibe targets this protein and inhibits the absorption ofintestinal cholesterol and alpha-tocopherol. In addition, thisprotein may play a critical role in regulating lipid metabolism.Polymorphic variations in this gene are associated with plasmatotal cholesterol and low-density lipoprotein cholesterol (LDL-C)levels and coronary heart disease (CHD) risk. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.
Background Reference 1:
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Background Reference 2:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 3:
Teslovich, T.M., et al. Nature 466(7307):707-713(2010)
Background Reference 4:
Pramfalk, C., et al. J. Lipid Res. 51(6):1354-1362(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-959

List Size:
400 ul

List Price:

$495.00

Datasheet
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