NR1I3 Antibody

Background:

This gene encodes a member of the nuclear receptorsuperfamily, and is a key regulator of xenobiotic and endobioticmetabolism. The protein binds to DNA as a monomer or a heterodimerwith the retinoid X receptor and regulates the transcription oftarget genes involved in drug metabolism and bilirubin clearance,such as cytochrome P450 family members. Unlike most nuclearreceptors, this transcriptional regulator is constitutively activein the absence of ligand but is regulated by both agonists andinverse agonists. Ligand binding results in translocation of thisprotein to the nucleus, where it activates or represses target genetranscription. These ligands include bilirubin, a variety offoreign compounds, steroid hormones, and prescription drugs.Multiple transcript variants encoding different isoforms have beenfound for this gene.