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Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).

NR3C2 Antibody

CATALOG NUMBER: 59-019

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Xenopus
Immunogen:
This NR3C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the Central region of human NR3C2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
107 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
NR3C2
Additional Names:
Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2, NR3C2, MCR, MLR
Protein Accession Number:
P08235
Protein Gi Number:
126885
Ncbi Gene Id Number:
4306
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes the mineralocorticoid receptor, whichmediates aldosterone actions on salt and water balance withinrestricted target cells. The protein functions as aligand-dependent transcription factor that binds tomineralocorticoid response elements in order to transactivatetarget genes. Mutations in this gene cause autosomal dominantpseudohypoaldosteronism type I, a disorder characterized by urinarysalt wasting. Defects in this gene are also associated with earlyonset hypertension with severe exacerbation in pregnancy.Alternative splicing results in multiple transcript variants.
Background Reference 1:
van Leeuwen, N., et al. Hypertension 56(5):995-1002(2010)
Background Reference 2:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 3:
Bouma, E.M., et al. Behav. Genet. (2010) In press :
Background Reference 4:
Bogdan, R., et al. Genes Brain Behav. 9(6):658-667(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-019

List Size:
400 ul

List Price:

$495.00

Datasheet
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