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Western blot of rat caudate lysate showing specific labeling of the ~75k NSF protein.
Western blot of rat caudate lysate showing specific labeling of the ~75k NSF protein.

NSF Antibody

CATALOG NUMBER: 50-183

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat NSF, conjugated to keyhole limpet hemocyanin (KLH).
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with human and mouse based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Predicted Molecular Weight:
75
Purification:
Affinity Purified
Clonality:
Polyclonal
Physical State:
Liquid
Concentration:
batch dependent
Storage Conditions:
NSF antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Nsf
Protein Accession Number:
Q9QUL6
Protein Gi Number:
81917630
Ncbi Gene Id Number:
60355
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
NSF (N-ethylmaleimide sensitive fusion protein) is a critical component of the SNARE (soluble NSF attachment protein receptors) protein complex that is involved in synaptic vesicle trafficking. Specifically, NSF has been found to be essential in membrane fusion. Furthermore, NSF has been recently demonstrated to bind other protein complexes such as AMPA receptor subunits (GluR2), GATE-16, LMA-1 and Rabs suggesting a more diverse role in the assembly of various protein complexes (Whiteheart et al., 2004).
Background Reference 1:
Schweizer FE, Dresbach T, DeBello WM, O’Connor V, Augustine G, Betz H (1998) Regulation of neurotransmitter release kinetics by NSF. Science 279(5354):1203-1206.
Background Reference 2:
Matveeva EA, Whitehart SW, Vanaman T, Slevin J (2001) Phosphorylation of the N-ethylmaleimide sensitive factor is associated with depolarization-dependent neurotransmitter release from synaptosomes. J Biol.Chem. 276(15): 12174-12181.
Background Reference 3:
Whitehart SW, Matveeva EA (2004) Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor. J Struct. Biol.146(1-2): 32-43.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-183

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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