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Western blot analysis in 293 cell line lysates (35ug/lane).
NUMBL Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in 293 cell line lysates (35ug/lane).

NUMBL Antibody

CATALOG NUMBER: 57-465

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This NUMBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-600 amino acids from the C-terminal region of human NUMBL.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
65 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
NUMBL
Additional Names:
Numb-like protein, Numb-related protein, Numb-R, NUMBL
Protein Accession Number:
Q9Y6R0
Protein Gi Number:
14194976
Ncbi Gene Id Number:
9253
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Background Reference 1:
Zhou, L., et al. Biochem. Biophys. Res. Commun. 392(3):409-414(2010)
Background Reference 2:
Blom, T., et al. Cancer Genet. Cytogenet. 186(2):103-109(2008)
Background Reference 3:
Ma, Q., et al. Cell. Signal. 20(6):1044-1051(2008)
Background Reference 4:
Passos Gregorio, S., et al. Schizophr. Res. 88 (1-3), 275-282 (2006) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-465

List Size:
400 ul

List Price:

$495.00

Datasheet
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