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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
OGDH Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

OGDH Antibody

CATALOG NUMBER: 57-045

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This OGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-410 amino acids from the C-terminal region of human OGDH.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
116 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
OGDH
Additional Names:
2-oxoglutarate dehydrogenase, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, Alpha-ketoglutarate dehydrogenase, OGDH
Protein Accession Number:
Q02218
Protein Gi Number:
160332299
Ncbi Gene Id Number:
4967
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes one subunit of the 2-oxoglutaratedehydrogenase complex. This complex catalyzes the overallconversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoAand CO(2) during the Krebs cycle. The protein is located in themitochondrial matrix and uses thiamine pyrophosphate as a cofactor.A congenital deficiency in 2-oxoglutarate dehydrogenase activity isbelieved to lead to hypotonia, metabolic acidosis, andhyperlactatemia. Alternative splicing results in multipletranscript variants encoding distinct isoforms.
Background Reference 1:
van Bever, Y., et al. Am. J. Med. Genet.143(7):763-767(2007)
Background Reference 2:
Shi, Q., et al. J. Biol. Chem. 280(12):10888-10896(2005)
Background Reference 3:
Habelhah, H., et al. J. Biol. Chem. 279(51):53782-53788(2004)
Background Reference 4:
McCartney, R.G., et al. J. Biol. Chem. 273(37):24158-24164(1998)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-045

List Size:
400 ul

List Price:

$495.00

Datasheet
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