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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in CEM cell line lysates (35ug/lane).

OPTN Antibody

CATALOG NUMBER: 59-579

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
66 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
OPTN
Additional Names:
Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
Protein Accession Number:
Q96CV9
Protein Gi Number:
317373403
Ncbi Gene Id Number:
10133
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes the coiled-coil containing proteinoptineurin. Optineurin may play a role in normal-tension glaucomaand adult-onset primary open angle glaucoma. Optineurin interactswith adenovirus E3-14.7K protein and may utilize tumor necrosisfactor-alpha or Fas-ligand pathways to mediate apoptosis,inflammation or vasoconstriction. Optineurin may also function incellular morphogenesis and membrane trafficking, vesicletrafficking, and transcription activation through its interactionswith the RAB8, huntingtin, and transcription factor IIIA proteins.Alternative splicing results in multiple transcript variantsencoding the same protein.
Background Reference 1:
McDonald, K.K., et al. J. Hum. Genet. 55(10):697-700(2010)
Background Reference 2:
Cheng, J.W., et al. Med. Sci. Monit. 16 (8), CR369-CR377 (2010) :
Background Reference 3:
Albagha, O.M., et al. Nat. Genet. 42(6):520-524(2010)
Background Reference 4:
Maruyama, H., et al. Nature 465(7295):223-226(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-579

List Size:
400 ul

List Price:

$495.00

Datasheet
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