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Western blot analysis in HUVEC cell line lysates (35ug/lane).
Western blot analysis in HUVEC cell line lysates (35ug/lane).

ORC2L Antibody

CATALOG NUMBER: 57-767

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This ORC2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human ORC2L.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
66 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ORC2
Additional Names:
Origin recognition complex subunit 2, ORC2, ORC2L
Protein Accession Number:
Q13416
Protein Gi Number:
8488999
Ncbi Gene Id Number:
4999
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The origin recognition complex (ORC) is a highly conservedsix subunits protein complex essential for the initiation of theDNA replication in eukaryotic cells. Studies in yeast demonstratedthat ORC binds specifically to origins of replication and serves asa platform for the assembly of additional initiation factors suchas Cdc6 and Mcm proteins. The protein encoded by this gene is asubunit of the ORC complex. This protein forms a core complex withORC3, -4, and -5. It also interacts with CDC45 and MCM10, which areproteins known to be important for the initiation of DNAreplication. This protein has been demonstrated to specificallyassociate with the origin of replication of Epstein-Barr virus inhuman cells, and is thought to be required for DNA replication fromviral origin of replication. Alternatively spliced transcriptvariants have been found, one of which is a nonsense-mediated mRNAdecay candidate.
Background Reference 1:
Huen, M.S., et al. Cell 131(5):901-914(2007)
Background Reference 2:
Siddiqui, K., et al. J. Biol. Chem. 282(44):32370-32383(2007)
Background Reference 3:
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Background Reference 4:
Radichev, I., et al. J. Biol. Chem. 281(32):23264-23273(2006)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-767

List Size:
400 ul

List Price:

$495.00

Datasheet
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