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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis in 293 cell line lysates (35ug/lane).

OSCAR Antibody

CATALOG NUMBER: 60-164

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This OSCAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-231 amino acids from the C-terminal region of human OSCAR.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
30 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
OSCAR
Additional Names:
Osteoclast-associated immunoglobulin-like receptor, Osteoclast-associated receptor, hOSCAR, Polymeric immunoglobulin receptor 3, PIgR-3, PIgR3, Poly-Ig receptor 3, OSCAR
Protein Accession Number:
Q8IYS5
Protein Gi Number:
311033418
Ncbi Gene Id Number:
126014
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Osteoclasts are multinucleated cells that resorb bone andare essential for bone homeostasis. This gene encodes anosteoclast-associated receptor (OSCAR), which is a member of theleukocyte receptor complex (LRC) protein family that plays criticalroles in the regulation of both innate and adaptive immuneresponses. Different from the other LRC members, OSCAR expressionis detected specifically in preosteoclasts or mature osteoclasts.OSCAR may be an important bone-specific regulator of osteoclastdifferentiation. Multiple alternatively spliced transcript variantsencoding different isoforms have been found for this gene.
Background Reference 1:
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Background Reference 2:
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Background Reference 3:
Herman, S., et al. Arthritis Rheum. 58(10):3041-3050(2008)
Background Reference 4:
Merck, E., et al. J. Immunol. 176(5):3149-3156(2006)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-164

List Size:
400 ul

List Price:

$495.00

Datasheet
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