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The purity of rh GPNMB / NMB was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh GPNMB / NMB was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

Osteoactivin Recombinant Protein

CATALOG NUMBER: 96-368

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ala 22 - Pro 486
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
52.9 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
GPNMB
Additional Names:
GPNMB, HGFIN, NMB, Osteoactivin
Protein Accession Number:
AAH32783
Ncbi Gene Id Number:
10457
Background:
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
Background Reference 1:
Weterman MA., et al., 1995, International Journal of Cancer 60 : 73–81.
Background Reference 2:
Abdelmagid, SM., et al., 2008, Exp Cell Res 314 (13): 2334–51.
Background Reference 3:
Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1): 26–37.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-368

List Size:
0.1 mg

List Price:

$495.00

Datasheet
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