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Western blot analysis of extracts from 293 cells treated with Etoposide using Phospho-p53 (Ser392) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from 293 cells treated with Etoposide using Phospho-p53 (Ser392) Antibody. The lane on the right is treated with the antigen-specific peptide.

p53 (phospho Ser392) Antibody

CATALOG NUMBER: 80-018

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
p53 (phospho Ser392) antibody was raised against a peptide sequence around phosphorylation site of serine 392 (P-D-S (p)-D) derived from Human p53.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of p53 only when phosphorylated at serine 392.
Predicted Molecular Weight:
53 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
TP53
Additional Names:
Antigen NY-CO-13, Cellular tumor antigen p53, Phosphoprotein p53, TP53, Tumor suppressor p53
Protein Accession Number:
NP_000537.3
Protein Gi Number:
120407068
Ncbi Gene Id Number:
7157
Background:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.
Background Reference 1:
Choi DW, et al. (2013) Mol Cell 51, 374-85
Background Reference 2:
Bagashev A, et al. (2013) Cell Cycle 12, 1569-77
Background Reference 3:
Shahar OD, et al. (2013) PLoS One 8, e78472

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

80-018

List Size:
0.1 mg

List Price:

$355.00

Out of stock

Datasheet
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