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p53 (phospho Thr387) Antibody

CATALOG NUMBER: 79-832

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
p53 (phospho Thr387) antibody was raised against a peptide sequence around phosphorylation site of threonine 387 (F-K-T (p)-E-G) derived from Human p53.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of p53 only when phosphorylated at threonine 387.
Predicted Molecular Weight:
43 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
TP53
Additional Names:
TP53, tumor protein p53, Tumor suppressor p53
Protein Accession Number:
NP_000537.3
Protein Gi Number:
120407068
Ncbi Gene Id Number:
7157
Background:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.
Background Reference 1:
Zakut-Houri R., EMBO J. 4:1251-1255(1985).
Background Reference 2:
Lamb P., Mol. Cell. Biol. 6:1379-1385(1986).
Background Reference 3:
Harlow E., Mol. Cell. Biol. 5:1601-1610(1985).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-832

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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