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Western blot analysis of lysed extracts from MCF cells untreated or treated with EGF using p70 S6 Kinase (Phospho-Ser411).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase (Phospho-Ser411).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed MCF7 cells using p70 S6 Kinase (Phospho-Ser411).
Western blot analysis of lysed extracts from MCF cells untreated or treated with EGF using p70 S6 Kinase (Phospho-Ser411).

p70 S6 Kinase (phospho Ser411) Antibody

CATALOG NUMBER: 79-221

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
p70 S6 Kinase (Phospho-Ser411) antibody was raised against a peptide sequence around phosphorylation site of serine 411 (I-R-S (p) -P-R) derived from Human p70 S6 Kinase.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of p70 S6 Kinase only when phosphorylated at serine 411.
Predicted Molecular Weight:
70 85 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
RPS6KB1
Additional Names:
S6K, PS6K, S6K1, STK14A, p70-S6K, p70S6KA, p70-alpha, S6K-beta-1, p70(S6K)-alpha, MACS, PRKCSL, KS6B1, P70-S6K, RPS6KB1, S6K
Protein Accession Number:
NP_003152.1
Protein Gi Number:
4506737
Ncbi Gene Id Number:
6198
Background:
Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.
Background Reference 1:
Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851Papst PJ, et al. (1998) J Biol Chem. 273 (24): 15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 cLe, X. F, et al. (2003) Oncogene 22: 484–97

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-221

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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