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Western blot analysis of extracts from 293 cells treated with UV using p90 RSK (Phospho-Thr573) Antibody. The lane on the right is treated with the antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p90 RSK (Phospho-Thr573) antibody (left) or the same antibody preincubated with blocking peptide (right).
Western blot analysis of extracts from 293 cells treated with UV using p90 RSK (Phospho-Thr573) Antibody. The lane on the right is treated with the antigen-specific peptide.

p90 RSK (phospho Thr573) Antibody

CATALOG NUMBER: 79-791

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
p90 RSK (phospho Thr573) antibody was raised against a peptide sequence around phosphorylation site of threonine 573 (L-M-T (p)-P-C) derived from Human p90 RSK.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
The antibody detects endogenous levels of P90RSK only when phosphorylated at threonine 573.
Predicted Molecular Weight:
95 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
RPS6KA1
Additional Names:
KS6A1, p90RSK1, RSK1, RPS6KA1
Protein Accession Number:
NP_002944.2
Protein Gi Number:
292457
Ncbi Gene Id Number:
6195
Background:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.
Background Reference 1:
Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206.
Background Reference 2:
Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 - 19048.
Background Reference 3:
Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 - 1835.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-791

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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