PABPC4 Antibody

Background:

Poly(A)-binding proteins (PABPs) bind to the poly(A) tailpresent at the 3-prime ends of most eukaryotic mRNAs. PABPC4 orIPABP (inducible PABP) was isolated as an activation-induced T-cellmRNA encoding a protein. Activation of T cells increased PABPC4mRNA levels in T cells approximately 5-fold. PABPC4 contains 4RNA-binding domains and proline-rich C terminus. PABPC4 islocalized primarily to the cytoplasm. It is suggested that PABPC4might be necessary for regulation of stability of labile mRNAspecies in activated T cells. PABPC4 was also identified as anantigen, APP1 (activated-platelet protein-1), expressed onthrombin-activated rabbit platelets. PABPC4 may also be involved inthe regulation of protein translation in platelets andmegakaryocytes or may participate in the binding or stabilizationof polyadenylates in platelet dense granules. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.