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Western blot analysis in Hela cell line lysates (35ug/lane).
Western blot analysis in Hela cell line lysates (35ug/lane).

PABPN1 Antibody

CATALOG NUMBER: 58-751

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This PABPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-298 amino acids from the C-terminal region of human PABPN1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
33 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PABPN1
Additional Names:
Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1, PABPN1, PAB2, PABP2
Protein Accession Number:
Q86U42
Protein Gi Number:
46403176
Ncbi Gene Id Number:
8106
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes an abundant nuclear protein that bindswith high affinity to nascent poly(A) tails. The protein isrequired for progressive and efficient polymerization of poly(A)tails on the 3' ends of eukaryotic genes and controls the size ofthe poly(A) tail to about 250 nt. At steady-state, this protein islocalized in the nucleus whereas a different poly(A) bindingprotein is localized in the cytoplasm. An expansion of thetrinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end ofthe coding region of this gene leads to autosomal dominantoculopharyngeal muscular dystrophy (OPMD) disease. Multiple splicevariants have been described but their full-length nature is notknown. One splice variant includes introns 1 and 6 but no proteinis formed.
Background Reference 1:
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Background Reference 2:
Hurt, J.A., et al. J. Cell Biol. 185(2):265-277(2009)
Background Reference 3:
Kuo, H.C., et al. J. Neurol. Sci. 278 (1-2), 21-24 (2009) :
Background Reference 4:
Tavanez, J.P., et al. PLoS ONE(7), E6418 (2009) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-751

List Size:
400 ul

List Price:

$495.00

Datasheet
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