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PAK2 (phospho Ser197) Antibody

CATALOG NUMBER: 79-861

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
PAK2 (phospho Ser197) antibody was raised against a peptide sequence around phosphorylation site of Serine 197 (T-R-S (p)-V-I) derived from Human PAK2.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of PAK2 only when phosphorylated at serine 197.
Predicted Molecular Weight:
58 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PAK2
Additional Names:
gamma-PAK, PAK65, PAKI, PAK 2
Protein Accession Number:
NP_002568.2
Protein Gi Number:
32483399
Ncbi Gene Id Number:
5062
Background:
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Background Reference 1:
Martin G.A., EMBO J. 14:1970-1978(1995).
Background Reference 2:
The MGC Project Team; Genome Res. 14:2121-2127(2004).
Background Reference 3:
Olsen J.V., Cell 127:635-648(2006).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-861

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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