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Western blot analysis of PALMD in human bladder tissue lysate with PALMD antibody at 1 μg/ml.
Immunohistochemistry of PALMD in human bladder tissue with PALMD antibody at 2.5 μg/mL.
Western blot analysis of PALMD in human bladder tissue lysate with PALMD antibody at 1 μg/ml.
Trial Size

PALMD Antibody

CATALOG NUMBER: 8237

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (93%), Pig: (93%), Mouse: (86%)
Immunogen:
PALMD antibody was raised against a 15 amino acid peptide near the carboxy terminus of human PALMD.
The immunogen is located within amino acids 460 - 510 of PALMD.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
PALMD antibody can be used for detection of PALMD by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity:
PALMD antibody is human specific. At least two isoforms are known to exist.
Positive Control 1:
Cat. No. 1310 - Human Bladder Tissue Lysate
Predicted Molecular Weight:
Predicted: 61 kDa
Observed: 60 kDa
Purification:
PALMD antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
PALMD antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
PALMD antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
PALMD
Additional Names:
Palmdelphin, C1orf11, FLJ20271, PALML, Paralemnin-like protein
Protein Accession Number:
NP_060204
Protein Gi Number:
8923243
Ncbi Gene Id Number:
54873
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Palmdelphin (PALMD) is a member of the paralemmin families that are lipid-anchored proteins having a role in the cell shape control and cell dynamics (1,2). While Paralemmin proteins typically anchor to the cytoplasm through via palmytoylation and prenylation, PALMD is found predominantly in the cytosol (3). PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage (3-5). Abnormal genetic alterations in PALMD are observed in many malignant tumors (5).
Background Reference 1:
Hultqvist G, Ocampo Daza D, Larhammar D, et al. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One 2012; 7:e41850.
Background Reference 2:
Andreu N, Escarceller M, Feather S, et al. PALML, a novel paralemmin-related gene mapping on human chromosome 1p21. Gene 2001; 278:33-40.
Background Reference 3:
Hu B, Copeland NG, Gilbert DJ, et al. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Biochem. Biophys. Res. Commun. 2001; 285:1369-76.
Background Reference 4:
Dashzeveg N, Taira N, Lu ZG, et al. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis. 2014; 5:e1221.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8237

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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