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Western blot analysis of PANX1 in human ovary tissue lysate with PANX1 antibody at 1 μg/mL.
Immunofluorescence of PANX1 in human ovary tissue with PANX1 antibody at 20 μg/mL.
Western blot analysis of PANX1 in human ovary tissue lysate with PANX1 antibody at 1 μg/mL.
Trial Size

PANX1 Antibody

CATALOG NUMBER: 7097

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Rabbit polyclonal PANX1 antibody was raised against a 17 amino acid peptide near the amino terminus of human PANX1.
The immunogen is located within amino acids 70 - 120 of PANX1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
PANX1 antibody can be used for detection of PANX1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
Two transcript variants encoding different isoforms have been found for this gene.
Positive Control 1:
Cat. No. 1316 - Human Ovary Tissue Lysate
Positive Control 2:
Cat. No. 11-201 - Human Ovary Tissue Slide
Predicted Molecular Weight:
47 kDa
Purification:
PANX1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
PANX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
PANX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PANX1
Additional Names:
PANX1 Antibody: PX1, MRS1, UNQ2529, UNQ2529/PRO6028, Pannexin-1
Protein Accession Number:
NP_056183
Protein Gi Number:
39995064
Ncbi Gene Id Number:
24145
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PANX1 Antibody: The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
Background Reference 1:
Barbe MT, Monyer H and Bruzzone R. Cell-cell communication beyond connexins: the pannexin channels. Physiology 2006; 21:103-14.
Background Reference 2:
Baranova A, Ivanov D, Petrash N, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 2004; 83:706-16.
Background Reference 3:
Sohl G, Maxeiner S and Willecke K. Expression and functions of neuronal gap junctions. Nat. Rev. Neurosci. 2005; 6:191-200
Background Reference 4:
Bao L, Locovei S and Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett. 2004; 572:65-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7097

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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