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PARL Antibody

CATALOG NUMBER: 39-872

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Chicken, Human, Mouse, Non-Human Primate, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Chicken, Human, Mouse, Non-Human Primate, Rat
Immunogen:
Synthetic peptide to the C-terminus.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC, WB
Application Note:
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Purification:
Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Concentration:
batch dependent
Ncbi Official Symbol:
PARL
Additional Names:
Presenilin associated, rhomboid-like protein , PSARL, PSARL1, RHBDS1, PRO2207, PSENIP2
Protein Accession Number:
NP_001032728
Protein Gi Number:
143811433
Ncbi Gene Id Number:
55486
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PARL is a rhomboid protease which has been shown to be involved in mitochondrial remodeling. PARL has also been shown to have antiapoptotic activity and protects cells from mitochondrial-dependent apoptotic pathway.
Background Reference 1:
Jeyaraju DV, Xu L, Letellier MC, Bandaru S, Zunino R, Berg EA, McBride HM, Pellegrini L., Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology., Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18562-7.
Background Reference 2:
Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B., Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling., Cell. 2006 Jul 14;126(1):27-9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

39-872

List Size:
0.1 mg

List Price:

$626.00

Datasheet
Shipping Info

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