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PARP-10 Antibody [5H11]

CATALOG NUMBER: 36-172

Clonality:
Monoclonal
Tested Applications:
ICC, IP, WB
Host Species:
Rat
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Human
Immunogen:
Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag.
Conjugate:
Unconjugated
Tested Applications:
ICC, IP, WB
Application Note:
Immunocytochemistry:(1:50-1:200). Immunoprecipitation:(1:10). Western Blot:(1:50). Optimal conditions must be determined individually for each application.
Specificity:
Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region.
Clonality:
Monoclonal
Isotype:
IgG1
physical-state:
Liquid
Buffer:
Liquid. Cell culture supernatant containing RPMI, 10% FCS and 0.05% sodium azide.
Concentration:
batch dependent
Storage Conditions:
Stable for at least 1 year after receipt when stored at +4°C.
Ncbi Official Symbol:
PARP10
Additional Names:
ADP-ribosyltransferase Diphtheria Toxin-like 10; Poly(ADP-ribose) Polymerase-10
Protein Accession Number:
116248563
Protein Gi Number:
Q53GL7
Ncbi Gene Id Number:
84875
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PARP-10. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

36-172

List Size:
1 ml

List Price:

$463.00

Datasheet
Shipping Info

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