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PARP-3 [ARTD3] high purity Recombinant Protein

CATALOG NUMBER: 90-342

Specifications
source-species:
Sf21 cells
Species:
Human
source-species:
Sf21 cells
Recombinant Protein Sequence:
Human full-length PARP-3 [ARTD3] is fused to a HA-tag and a His-tag.
Fusion Tag:
His Tag
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
>10U/mg protein (only monoADP-ribosyl transferase activity).
Purity:
>98% (SDS-PAGE)
physical-state:
Liquid
Buffer:
In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.
Concentration:
Lot dependent (0.2-1mg/ml)
Storage Conditions:
Stable for at least 6 months after receipt when stored at -80°C.
Ncbi Official Symbol:
PARP3
Additional Names:
Poly(ADP-ribose) Polymerase 3, ADP-ribosyltransferase Diphtheria Toxin-like 3, NAD(+) ADP-ribosyltransferase 3
Protein Accession Number:
Q9Y6F1
Protein Gi Number:
158634478
Ncbi Gene Id Number:
10039
Background:
PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-342

List Size:
10 ug

List Price:

$446.00

Datasheet
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