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Western blot analysis in A549 cell line lysates (35ug/lane).
Western blot analysis in A549 cell line lysates (35ug/lane).

PCGF2 Antibody

CATALOG NUMBER: 58-091

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PCGF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human PCGF2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
38 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PCGF2
Additional Names:
Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18, RNF110, ZNF144
Protein Accession Number:
P35227
Protein Gi Number:
462585
Ncbi Gene Id Number:
7703
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene contains a RING fingermotif and is similar to the polycomb group (PcG) gene products. PcGgene products form complexes via protein-protein interaction andmaintain the transcription repression of genes involved inembryogenesis, cell cycles, and tumorigenesis. This protein wasshown to act as a negative regulator of transcription and has tumorsuppressor activity. The expression of this gene was detected invarious tumor cells, but is limited in neural organs in normaltissues. Knockout studies in mice suggested that this protein maynegatively regulate the expression of different cytokines,chemokines, and chemokine receptors, and thus plays an importantrole in lymphocyte differentiation and migration, as well as inimmune responses.
Background Reference 1:
Jung, J.H., et al. Biochem. Biophys. Res. Commun. 400(4):523-530(2010)
Background Reference 2:
Zhang, X.W., et al. Mol. Cancer 9, 40 (2010) :
Background Reference 3:
Wang, W., et al. Int. J. Cancer 125(12):2836-2843(2009)
Background Reference 4:
Zhang, J., et al. Biochem. Biophys. Res. Commun. 375(2):252-255(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-091

List Size:
400 ul

List Price:

$495.00

Datasheet
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