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Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).
Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).

PCSK4 Antibody

CATALOG NUMBER: 58-777

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PCSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the N-terminal region of human PCSK4.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
83 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PCSK4
Additional Names:
Proprotein convertase subtilisin/kexin type 4, 3421-, Proprotein convertase 4, PC4, PCSK4 {ECO:0000312, EMBL:AAH363541}
Protein Accession Number:
Q6UW60
Protein Gi Number:
296439263
Ncbi Gene Id Number:
54760
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Proprotein convertases, including PCSK4, arecalcium-dependent serine proteases related to bacterial subtilisinsand to yeast kexin. These enzymes process precursor proteins totheir active forms by selective cleavage of the polypeptide atsites following paired basic amino acids. In mammals, this familycomprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405).Substrates for these enzymes range from prohormones to precursorsfor growth factors to cell surface receptors and viral surfaceglycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied byOMIM].
Background Reference 1:
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 2:
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Background Reference 3:
Batta, K., et al. J. Mol. Biol. 385(3):788-799(2009)
Background Reference 4:
Qiu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 102(31):11047-11052(2005)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-777

List Size:
400 ul

List Price:

$495.00

Datasheet
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